Even with surgery, radiation, and drug-based therapies, glioblastoma tumors are unlikely to be cured. The disease usually comes back and is fatal.
Glioblastoma tumors tend to vary on the cellular and molecular level, which means that a treatment that works against some cells might not work against others. Research is enabling better classification of tumors according to their underlying biology. The ultimate goal is to create focused drugs that can target specific mutations.
Nearly every treatment that is available to patients today exists because of a clinical trial.